![]() Measuring inactive levels of vitamin K-dependent proteins in the circulation is the method recommended by most experts, as it represents the systemic availability of both vitamin K1 and K2. The vitamin K-dependent Matrix Gla Protein (MGP) protects elastin from both calcification and degradation.Īlthough technically feasible, direct quantification of blood vitamin K levels is not an appropriate method to assess overall vitamin K status due to differences in bioavailability and half-life time between the two naturally occurring vitamin K forms (vitamin K1 and K2). ![]() Elastin is a major component of dynamic tissues such as lungs and arteries, and elastin calcification stimulates elastin degradation and vice versa. ![]() Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays an essential role. Coagulopathy and thromboembolism are prevalent in severe COVID-19, and these factors are associated with decreased survival. While the majority of people recover after mild symptoms, a portion of COVID-19 patients develops respiratory failure.
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